عنوان البحث | ملخص البحث | Research Abstract |
Reactive metabolites in early drug development: predictive in vitro tools | | Drug metabolism can result in the formation of highly reactive metabolites that are known to play a role in toxicity resulting in a significant proportion of attrition during drug development and clinical use. Thus, the earlier such reactiv |
Human variation and CYP enzyme contribution in benfuracarb metabolism in human in vitro hepatic models | | In vitro metabolism of benfuracarb in liver microsomes from seven species was studied in order to quantitate species-specific metabolic profiles and enhance benfuracarb risk assessment by interspecies comparisons. Using LC–MS/MS, a total of |
Comparative metabolism of benfuracarb in in vitro mammalian hepatic microsomes model and its implications for chemical risk assessment | | Human responses to the toxicological effects of chemicals are often complicated by a substantial interindividual variability in toxicokinetics, of which metabolism is often the most important factor. Therefore, we investigated human variati |
Estimation of health risk by using toxicokinetic modelling: A case study of polychlorinated biphenyl PCB153. | | To assess potential PCB153-associated human health effects and risks, it is necessary to model past exposure. PCB153 blood concentrations, obtained from the AMAP biomonitoring programme were used to extrapolate body burden and exposure to t |